Tetracycline

Tetracycline. If you’ve been in practice for more than a minute, you’ve written a script for it, probably hundreds of times. It sits in that unique category of drugs that’s both foundational and, in many ways, frustratingly complex. It’s not just another antibiotic; it’s a time-tested workhorse with a spectrum of activity that, frankly, we don’t see in newer, more targeted agents. But its use has evolved dramatically from its early days as a first-line broad-spectrum option.