Bupropion

Let me start by describing bupropion for you, not from the textbook, but from the chair in my office. It’s an atypical antidepressant, classified as a norepinephrine-dopamine reuptake inhibitor (NDRI). That’s the dry definition. In practice, it’s the one I reach for when a patient comes in flattened by depression but tells me, “I can’t afford to be foggy or gain twenty pounds,” or when someone’s hands shake as they light another cigarette, desperate to quit but terrified of the withdrawal.