Minocycline

Minocycline is a semi-synthetic, second-generation tetracycline antibiotic. While its primary and long-standing indication is for the treatment of bacterial infections, its unique pharmacological profile has propelled it into the spotlight for a range of non-antibiotic applications. This molecule penetrates tissues exceptionally well, including the central nervous system and skin, and possesses distinct anti-inflammatory, immunomodulatory, and purported neuroprotective effects. In clinical practice, we’re increasingly seeing it used off-label for conditions where chronic inflammation is a key driver of pathology.