Dipyridamole

Let’s talk about dipyridamole. If you’re like most clinicians, you probably first encountered it as part of the old “Aggrenox” formulation for secondary stroke prevention, or maybe you’ve ordered a cardiac stress test using it as a pharmacologic agent. It’s one of those drugs that sits in the background, not as flashy as the novel oral anticoagulants, but with a fascinating pharmacology and some very specific, evidence-backed niches. I want to walk you through it not just as a monograph, but with the kind of context you’d get over a coffee after grand rounds—the real-world nuances, the patient stories, and the clinical head-scratchers that never make it into the official prescribing information.