Fosfomycin: Single-Dose Efficacy for Uncomplicated UTIs - Evidence-Based Review

Product Description: Fosfomycin is a unique, broad-spectrum bactericidal antibiotic with a distinct chemical structure and mechanism of action. Originally isolated from Streptomyces species, it is formally known as fosfomycin trometamol for oral use and fosfomycin disodium for intravenous administration. Its primary medical use is in the treatment of uncomplicated lower urinary tract infections (UTIs), particularly those caused by Escherichia coli and Enterococcus faecalis. It works by irreversibly inhibiting an early step in bacterial cell wall synthesis, making it effective even against some multidrug-resistant pathogens.