Lisinopril: Effective Blood Pressure Control and Cardiac Protection - Evidence-Based Review

Product Description Lisinopril is an orally active, long-acting angiotensin-converting enzyme (ACE) inhibitor used primarily in the management of hypertension and heart failure, and for the improvement of survival following acute myocardial infarction in clinically stable patients. It is a synthetic peptide derivative and a lysine analogue of enalaprilat, the active metabolite of enalapril. Unlike many prodrug ACE inhibitors, lisinopril itself is biologically active. Its mechanism centers on the suppression of the renin-angiotensin-aldosterone system (RAAS), leading to vasodilation, reduced blood volume, and decreased cardiac workload.