Nizoral (ketoconazole) is a potent antifungal agent available in both topical and oral formulations. This comprehensive monograph details its mechanism of action, approved indications for fungal infections like seborrheic dermatitis and tinea versicolor, and important safety considerations. Learn about the clinical evidence, proper usage, and why its systemic use is now highly restricted due to serious risks. Let’s talk about Nizoral. If you’ve been in practice for a while, you’ve got a bottle of the shampoo in your clinic cupboard and you remember when the oral tablets were a first-line workhorse for stubborn fungal infections.