Diacerein

Diacerein is a pharmaceutical-grade compound, classified as an anthraquinone derivative, used primarily in the management of osteoarthritis (OA). Unlike typical non-steroidal anti-inflammatory drugs (NSAIDs), diacerein does not directly inhibit cyclooxygenase (COX) enzymes. Instead, it functions as a slow-acting, disease-modifying agent that targets the underlying pathological processes of cartilage degradation and synovial inflammation. Its active metabolite, rhein, is responsible for its therapeutic effects. This monograph provides a comprehensive, evidence-based review of diacerein, detailing its pharmacology, clinical efficacy, safety profile, and practical use in clinical settings.