Indocin: Potent Anti-Inflammatory and Analgesic for Gout and Inflammatory Arthritis - Evidence-Based Review

Product Description: Indocin, known generically as indomethacin, is a potent nonsteroidal anti-inflammatory drug (NSAID) available in oral capsule, sustained-release capsule, and suppository forms. It functions as a non-selective inhibitor of cyclooxygenase (COX-1 and COX-2) enzymes, leading to a pronounced reduction in prostaglandin synthesis. This mechanism underpins its powerful anti-inflammatory, analgesic, and antipyretic properties. It is a cornerstone therapy for managing moderate to severe inflammatory conditions, particularly in rheumatology, and is uniquely positioned for certain specific indications like closing a patent ductus arteriosus in neonates.