Prazosin: Nightmare and Hyperarousal Suppression in PTSD - Evidence-Based Review

Product Description Prazosin is a quinazoline derivative, a selective alpha-1 adrenergic receptor antagonist. It is primarily available as an oral tablet, though compounded formulations exist. While its original and primary FDA-approved indication is for the treatment of hypertension, its off-label use in managing trauma-related nightmares and sleep disturbances in Post-Traumatic Stress Disorder (PTSD) has become a significant, evidence-supported application in psychiatric and sleep medicine. It works by blocking alpha-1 receptors in the brain and periphery, leading to vasodilation and, crucially for neuropsychiatric applications, a hypothesized reduction in noradrenergic hyperactivity in the amygdala and prefrontal cortex during sleep.